王璐红

个人简介：

王璐红，理学博士，助理研究员。

研究方向：

1、靶向小分子抑制剂的设计、合成与优化

2、肿瘤耐药机制的研究

教育经历：

2019.9-2023.10 沈阳药科大学-药物化学-博士

2016.9-2019.6 大连医科大学-药物化学-硕士

2012.8-2016.6 大连医科大学-药学-学士

工作经历：2023.11-至今 大连理工大学医学部-博士后

论文成果：
[1] Luhong Wang, Fei Xie, Shujing Li, Guanglu Guo, Qiyu Song, Xinyu Yuan, Jie Kang, Yulin Li, Aoli Wang, Huijian Wu, Youjun Xu. Pan-EGFR inhibitor targeting EGFR 19del, L858R/T790M and C797S triple-mutations: Design, synthesis, and pharmacological evaluation. Bioorganic chemistry, 2025, 164, 108878.

[2] Luhong Wang, Yong Zhang, Tao Yu, Huijian Wu. The Role and Mechanism of Deubiquitinase USP7 in Tumor-Associated Inflammation. Biomedicines, 2024, 12, 2734.

[3] Luhong Wang, Xueting Ding, Kai Wang, Ruchan Sun, Ming Li, Fang Wang, Youjun Xu. Structure-based modification of ortho-amidophenyl aminopyrimidines as a novel mutant EGFR inhibitor against resistant non-small cell lung cancer. Journal of Molecular Structure, 2023, 1274, 134499.

[4] Luhong Wang, Min Ai, Jiawen Yu, Lingling Jin, Changyuan Wang, Zhihao Liu, Xiaohong Shu, Zeyao Tang, Kexin Liu, Hui Luo, Wenshun Guan, Xiuli Sun, Xiaodong Ma. Structure-based modification of carbonyl- diphenylpyrimidines (Car-DPPYs) as a novel focal adhesion kinase (FAK) inhibitor against various stubborn cancer cells. European Journal of Medical Chemistry, 2019, 172, 154‒162.